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Services

Developability
& Screening

Process-forward. Anchors on the candidate-funnel use case – screen many, advance few. Best for Al-library / lead-selection programs.

  • 22 developability assays
  • Side-by-side screening
  • Volume discounts at scale
  • Custom panels on request

Value drivers

Closed loop development: express, purify, characterize, repeat

Candidates that fail developability late in the pipeline cost months of time and millions of dollars in re-work. Three places early developability screening changes the math.

  1. Late Liabilities = Late Costs

    The pipeline-burn problem

    • Aggregation found at IND-tox = restart program
    • Polyreactivity found in PK = clinical hold risk
    • Viscosity found at formulation = SC dose blocked

  2. AI Libraries Need Triage

    The candidate-funnel problem

    • Al workflows generate 50-500 antibody candidates
    • Most have at least one developability liability
    • Without triage, you advance the wrong ones

     

  3. Developability Predicts Manufacturing

    The downstream-prediction problem

    • Tm predicts process robustness
    • Polyreactivity predicts PK + clearance
    • Aggregation predicts formulation latitude

Six Categories, Twenty-Two Assays

The 22-assay triage panel

The full menu – organized by what each assay tells you. Run as a complete panel, a curated subset, or à la carte against your specific liabilities of concern.

Scientist working in a Celltheon laboratory Scientist working in a Celltheon laboratory

How screening works

Standard screening engagement runs in four steps. We multiplex where possible to compress timeline and we deliver a ranked dataset with go/no-go recommendations.

  1. WEEK 1

    Sample Intake

    • Sponsor sends candidate panel
    • Concentration + buffer normalized
    • Panel selection finalized
  2. WEEK 2-3

    Parallel Assay Run

    • Multiplexed assays run side-by-side
    • Plate-based formats for HTP
    • Custom add-ons run in parallel
  3. WEEK 3-4

    Data Analysis

    • Per-assay scoring vs. cutoffs
    • Per-candidate liability heatmap
    • Ranked candidate list
  4. WEEK 4-5

    Report + Recommendation

    • Full report with raw + ranked data
    • Recommended advance / repeat / kill
    • Optional consultation walkthrough
  5. OUTPUT

    Data Analysis

    • Ranked candidate dataset
    • Per-candidate liability heatmap
    • Advance / repeat / kill recommendations

Engagement options

Three ways to use the panel — from full screening to flexible à la carte and bundled options

Start with the full panel as the primary screening offer, then adjust scope with à la carte or bundled configurations. Volume-based pricing supports larger candidate sets by lowering the per-sample rate.

  • Primary offer
    Primary

    All 22 assays on N candidates

    Complete triage; ranked output with recommendations

    • All 22 assays per candidate
    • Side-by-side ranking + heatmap
    • Volume tiers: 10, 25, 50, 99+ samples
    • Walkthrough consultation included

    Ideal for: Al library triage, lead selection, hit-to-lead funnels

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  • À la catre

    Pick specific assays for known liabilities

    Target your screen at the liability you’re hunting

    • Pick any subset from the 22-assay menu
    • Per-sample volume pricing applies
    • Quick-turn quote and sample receipt
    • Single-liability or multi-liability scopes

    Ideal for: programs with a known liability concern (e.g., viscosity, polyreactivity)

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  • Bundled with CLD/PD

    Discounted when paired with a program

    Runs inside a Celltheon CLD or PD scope

    • Discounted vs. à la carte rate
    • Material from transient or CLD scope
    • Single contract, one team, one timeline
    • Pairs upstream with Transient Services

    Ideal for: programs already running Celltheon CLD or transient

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Frequently Asked Questions

Quick answers
to common questions

Quick answers about SUPERCELL™.

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