Product
CHO cell culture
media & feeds
Key benefits
Why chemically
defined matters
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Batch-to-Batch Consistency
No animal components or hydrolysates — every lot delivers reproducible cell culture performance and product quality.
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Easier Downstream Purification
Absence of undefined proteins simplifies purification and reduces contamination risk.
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Regulatory Compliance
Eliminates animal-derived risks; supports compliance with GMP and Drug Master File submissions.
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Precise Process Control
Known formulations allow scientists to pinpoint optimal nutrient concentrations and feeding strategies.
Key benefits
High-yield
protein production
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>14 g/L
mAb titers demonstrated in optimized fed-batch
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2x
Protein titer increase vS. competing products
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>90%
Cell viability maintained throughout culture
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3-5x
Fed-batch productivity boost with complementary feeds
How leading media systems achieve high yields
One media for all workflows
Best-in-class platform provides an all-in-one solution for all stages of development workflows:
01
02
03
04
05
Cloning medium
Supports GS-CHO cloning methods; sterility-tested.
Applications of ELIXIR™
ELIXIR™ applications across R&D to preclinical development — from early studies to production-ready material
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Batch
Simplified, single-inoculation process
- Simple seeding and culture initiation
- Ideal for early process screening
- High-yield media deliver strong base titers
- Minimal hands-on time required
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Fed-batch
Standard for biopharmaceutical manufacturing
- Concentrated feeds replenish amino acids and vitamins
- 3-5× productivity vs. batch conditions
- Bolus feeding regimens (3% v/v) from day 3 every other day
- Sustains peak cell density for 14-21 day cultures
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Perfusion
Continuous process for highest intensities
- Verified against volumetric productivity (VP)
- Cell-specific perfusion rates (CSPR) tested
- Steady-state culture with continuous media exchange
- High or moderate cell density conditions both yielding high titers
- Simulated perfusion in flask or continuous perfusion in bioreactor
Comparative pool titers
Scalability: from lab
to GMP manufacturing
Subtitle
Scalability by design
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Rational Media Design
Sequential, complementary development methods ensure performance is maintained as volume increases.
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Liquid & Powder Formats
Available in ready-to-use liquid and powder formats for flexibility at all scales.
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Process Parameter Robustness
Media verified for pH, osmolality, endotoxin, bioburden, and component quantitative analysis.
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Platformed Processes for Rapid Scaleup
Fully platformed and transferable process parameters for shake flask and bioreactor expression.
Protein Quality: Beyond Just Titer
Storage conditions
Practical parameters & storage guidance
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Powder Medium
Store at 2-8°C, dry environment, protected from light. Reconstituted medium: 2-8°C, protected from light.
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Liquid Medium
Store at 2-8°C. Once opened under sterile conditions, use within 1-4 weeks. Serum-free up to 2 weeks.
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Available Formats
Liquid (500 mL, 1 L) and powder (5 L, 10 L, 25 L reconstituted volume) for process-scale flexibility.
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Rapid Prototyping
Custom prototype formulations manufactured (up to 200 L) within 7 working days for process development needs.
Summary
The ideal CHO media system —synthesized from leading commercial platforms
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Chemically defined, ADCF, serum-free formulation ensuring batch-to-batch
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Demonstrated titers >14 g/L mAb in standard fed-batch
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Integrated system: one media for all steps
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Human-like glycosylation, preserved and tunable for biosimilars
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Scalable from 0.3mL deep well plates to 20,000 L+ bioreactors with consistent protein tier trends
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Flexible process modes: batch, fed-batch, and perfusion
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Full regulatory support: MP manufacturing, ISO certification
The right CHO media platform shortens time-to-market, maximizes product yield, and ensures quality from early development through commercial launch.
