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Product

SUPERCELL™:
The next generation in CHO-K1 technology

A next-generation CHO-K1 host cell line purpose-built for difficult-to-express proteins, enabling high titers, stable CQAs, and predictable scale-up.

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Technology foundation

SUPERCELL™
CHO-K1 lineage

  1. Proven CHO-K1 foundation

    Built on the KAO / Puck / Chasin original CHO-K1 cell line – trusted across biopharma.

  2. Directed evolution

    SUPERCELL™ was developed via phenotypic selection to improve folding, redox balance, and cell stability.

  3. Proprietary Evolution Path

    Celltheon owns this cell line and continues to evolve it through selection and engineering, ensuring it remains the leading CHO-K1 cell line.

  4. Why lineage matters

    Within the proven CHO-K1 ecosystem, SUPERCELL™ delivers higher expression, stable CQAs, and predictable scale-up.

what we offer

Biopharma services built
for speed, quality, and scale

Transient Expression Platform

OmniCHO™

Fast, high-fidelity transient expression built on the SUPERCELL™ lineage. Enables early candidate evaluation with CQAs aligned to downstream development.

  • Antibody Discovery
  • Variant Screening & Development

Platform performance

SUPERCELL™ — engineered for consistent quality, predictable scale-up, and high productivity

SUPERCELL™ is a next-generation CHO-K1 cell line optimized for consistent product quality, efficient scale-up, and high productivity.

  1. Product quality

    High monomer content and tunable CQAs based on a proven CHO-K1 lineage.

  2. Easy Scale-up

    Fast growth, no clumping, and low oxygen demand for predictable scale-up.

  3. High Productivity

    High cell densities and titers, including difficult-to-express proteins.

  4. Long-term stability

    Stable metabolism and performance across extended culture generations.

Data overview

Protein expression performance

Difficult Molecules, Exceptional Titers

SUPERCELL™ delivers reliable pool titers of 6–14 g/L across challenging protein formats, including bispecifics and scFvs. This reduces screening effort and accelerates candidate selection.

Molecule format
Fc-fusion 13.79g/L 13.79g/L
Lipoprotein 10.69g/L 10.69g/L
4-Chain Bispecific 11.01g/L 11.01g/L
Nanobody fusion 11.41g/L 11.41g/L
Braikinumab 10.41g/L 10.41g/L
Adalimumab 9.36g/L 9.36g/L
Trastuzumab 8.84g/L 8.84g/L
Seribantumab 8.39g/L 8.39g/L
Lenzilumab 7.8g/L 7.8g/L

Who SUPERCELL™ is built for

Designed for difficult molecules, complex formats, and scale-up certainty

Designed for molecules that fail on standard CHO platforms due to folding, stability, or secretion limitations — enabling expression where others stall.

  • Difficult-to-express proteins

    Enables expression of molecules that fail on standard CHO platforms due to folding, stability, or secretion constraints.

    • Low yield
    • Aggregation
    • Misfolding

  • Complex antibody
    formats

    Optimized for complex modalities like scFvs, bispecifics, and Fc-fusions where quality and titers are hard to sustain.

    • scFv
    • bispecific
    • Fc-fusion

  • Programs with scale-up risk

    Ensures early expression success translates reliably from plates to bioreactors without re-optimization or drift.

    • Plate → bioreactor consistency

  • Predictable CQAs
    required

    Provides consistent control of critical quality attributes across development stages to reduce regulatory risk and downstream surprises.

    • Stability
    • Aggregation
    • Glycosylation
Frequently asked questions

Quick answers
to common questions

Quick answers about timelines, quality, and how to work with Celltheon.

Celltheon builds biotech technology platforms and delivers end-to-end solutions that bridge early drug development and manufacturing.

We support biotech and biopharma teams from discovery through preclinical development and manufacturing readiness.

Our offering spans DNA, protein production, engineering, developability, assays, stable cell lines, conjugation, and process development.

Both. Programs can use an integrated workflow or select the individual services and technologies they need.

Yes. Choose platform transfer to your team or a service model executed by Celltheon scientists.

We begin with your goals, molecule, timeline, and deliverables, then provide a clear technical plan and project scope.

We share relevant case studies, quality documentation, platform data, and a project-specific package aligned with your requirements.

Discuss your molecule with our scientists

We don’t workaround — we innovate
and deliver

Explore whether SUPERCELL™ is the right host cell platform for your specific protein format.

Talk to a Scientist